Tools for Problem SolvingExpertise Capitalising on the many decades of academic and industrial experience of its founders Dr Cliff Elcombe and Prof. Roland Wolf, the company combines scientific excellence with effective project management to deliver cost effective solutions. A key part of the success of CXR Biosciences in problem solving is it’s multi-disciplinary team, combining extensive expertise in a range of conventional techniques and cutting edge technologies. The judicious use of appropriate tools and techniques maximises the chance of successfully elucidating toxic mechanisms. Toxicology and molecular biology In addition to the standard toxicokinetic and toxicology studies that are performed routinely at CXR Biosciences, an experienced team of molecular biologists is used to develop new assays or models where required. This approach can, for example, include the cloning of rodent and human receptors to compare species differences or the development of an assay to demonstrate the mechanism of toxicity of a chemical. Further information on other techniques can be accessed below:
Microarray services.
Using gene-chip microarrays and sophisticated bioinformatic analysis software, CXR Biosciences generates biologically relevant hypotheses for mechanisms of toxicity. Applied in this focused and thoughtful manner transcriptional profiling provides a powerful approach towards elucidating and understanding toxic mechanisms. As the longest-standing Agilent-accredited microarray service provider in the UK, we supply the flexibility and expertise you require from your array service partner.
Toxicity reporter cell lines.
In vitro models for the rapid assessment of mechanisms of toxicity. Specific gene promoters associated with toxicity / anti-cancer activity have been linked to biomarker reporter systems. These models provide a more rapid & cost effective means to assess modes of toxicology. CXR Biosciences can also develop customised reporter systems that measure changes in the transcriptional regulation of any gene of interest, which can be applied to specific toxicological issues.
Toxicity reporter mice.
In vivo models for the rapid assessment of potential mechanisms of toxicity. The promoters of genes activated in response to toxic agents have been linked to proprietary reporters, to provide rapid in vivo methods for the assessment of candidate compounds.
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