Publications
Time-Dependent and Compartment-Specific Effects of In Utero Exposure to Di(n-butyl) Phthalate on Gene/Protein Expression in the Fetal Rat Testis as Revealed byTranscription Profiling and Laser Capture Microdissection. Plummer S, Sharpe RM, Hallmark N, Mahood IK, Elcombe C, (2007)Toxicological Sciences 97(2), pp520–532. > Access paper here
Oral Presentations
British Toxicology Society Perfluorooctanoic Acid Workshop, Shrigley Hall, Cheshire, 5th-6th November 2007 Dr Cliff Elcombe
Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action.
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Toxicogenomics Meeting, Nice, 1st October 2007 Dr Simon Plummer
Laser Microdissection Targetted Transcription profiling and Pathways Analysis for Mechanism Based Hazard Assessment.
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Poster Presentations
10th European ISSX meeting, Vienna, Austria, 18-21st May 2008
A Novel Panel of Double "Humanised" & Knockout PXR and CAR Mouse Models
British Toxiocology Society Annual Congress, University of Surrey, Guildford, 15-18th April 2007
Comparison of Gene Expression Changes in Whole Pancreas With Isolated Pancreatic acinar cells of rats fed diets containing Wyeth 14,643 or Ammonium Perfluorooctanoate (APFO) Download pdf
Characterisation of APFO Induced Hepatomegaly in Rats Download pdf
Society of Toxicology, 46th Annual Meeting and Tox Expo, Charlotte, NC, 25-29th March 2007
Improved "Humanised" PXR and CAR Mouse Models Download pdf
In vitro metabolites of Arylamine hair dyes in human hepatic microsomes and human hepatocytes Download pdf
Comparison of 1-colour and 2-colour methods for microarray-based transcription profiling analysis with laser captured micro-dissected analysis Download pdf
Identification of region specific gene expression changes and signalling pathways affected by Di-buty-phthalate in foetal rat testes Download pdf
General Poster Presentations
Comparison of 1 cycle and 2 cycle RNA Labelling Methods for Microarray-based Transcription Profiling Analysis with Laser Capture Microdissected Samples Download pdf
The Effects of Ammonium Perfluorooctanoate (APFO) on the Transcriptional Profile of Pancreas and Liver of Male Rats Download pdf
High Throughput Inhibition Screening of Five Major Human cytochrome P450 Enzymes using an In vitro Substrate cocktail Download pdf
Hepatic Metabolism of Aromatic Amine Hair Dye Components as Compared with that of 2-Aminofluorine Download pdf
Novel PXR/CAR Humanised Mouse Models to predict Human Drug Disposition and Toxicity Download pdf
Different Effects of PPAR alpha and PPAR gamma Agonists on Hepatocytes S-phase and Apoptosis Download pdf
