transADMET™ mice
Transforming compound development by better predicting ADMET in man
Current preclinical models can be poorly predictive of absorption, distribution, metabolism, excretion and toxicology (ADMET) in man. This inability to translate animal results to man is driven by profound interspecies differences in the levels and functions of proteins involved in ADMET, and is a major reason for development failure in the pharmaceutical and chemical industries.
In response, CXR Biosciences and Taconic Artemis have developed the transADMET™ mice panel via an ITI Life Sciences sponsored research program. Key murine ADMET genes have either been exchanged for their human counterparts, or knocked out for use as controls. Once all the models are commercially available, they will be packaged in three panels representing critical pathways in compound metabolism and disposition:
transADMET™ mice Brochure
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Availability
The first receptor models and cytochrome P450 models are available now, with additional models to follow.
Contract services: CXR are co-exclusive suppliers of contract research services using transADMET mice. We also offer consultancy and advice to our customers.
For more information on contract research services at CXR using the transADMET™ mice, contact us here or at transADMET@cxrbiosciences.com.
Off the shelf mice: Mice may be purchased directly from Taconic. To purchase transADMET™ mice, please visit the relevant model webpages:
The HRN™ mouse.
A unique mouse model with no hepatic CYP450 activity, that can be used to determine ADME, PK and efficacy in the absence of confounding first-pass metabolism.
In vivo screening PK studies.
Small, cost effective PK studies, where multisampling techniques in a mouse mean compound and animal use is minimised.
Drug development solutions.
CXR combines proprietary technologies with improved application of traditional preclinical techniques and assays, including
in vitro and
in vivo ADME and Toxicology studies; cell culture; and an extensive analytical capability.
