A cost-effective method of generating early PK data that minimises animal and compound use
Screening PK studies in mice or rats use a serial sampling procedure coupled with a proprietary bioanalytical technique that allows multiple samples to be taken from the same animal.
Critically, because there are typically only three animals per group, relatively little test compound is needed.
Inter-animal variability is not an issue as multiple samples are taken from the same animal.
This technique minimises animal use – of particular importance when using transgenic animals.
transADMET™ mice.
Key murine genes involved in the metabolic response to drugs (e.g. PXR, CAR, cytochrome P450s, drug transporters) are replaced with their human equivalents to give a more predictive and “human-like” response.
